Health Questions and Answers

Archive for April, 2008

Question: Which drugs are commonly associated with the development of a clinical syndrome of lupus and a positive ANA?

Tuesday, April 29th, 2008

Answer: Historically, a clinical syndrome of arthritis, fever, rash, and positive ANA was seen in some patients after initiating antihypertensive treatment with hydralazine. Since then, the development of circulating ANA or clinical symptoms has been demonstrated with many drugs, including procainamide, diphenylhydantoin, isoniazid, chlorpromazine, d-penicillamine, sulfasalazine, methyldopa, and quinidine. So-called slow acetylators more commonly develop […]

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Question: Why is it helpful to know which specific ANA is present in a given patient?

Tuesday, April 29th, 2008

Answer: Although no laboratory test is absolutely diagnostic for a rheumatic disease, the presence of certain autoantibodies in the appropriate clinical setting can be helpful. Some common disease associations include: Ro/SSA DS DNA Sm Jo-1 Centromere SCL-70 SLE, neonatal lupus syndrome, subacute lupus, Sjögren’s syndrome, RA SLE SLE Polymyositis with pulmonary involvement CREST syndrome Systemic […]

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