Answer: A true fever is an increase in core temperature caused by elevation of the hypothalamic setpoint. This causes the body to attempt to generate heat (e.g., by shivering) to elevate the body’s core temperature. In contrast, hyperthermia results in an elevated temperature without altering the set-point, so the body attempts to cool itseff to [...]

Answer: For bony or soft tissue metastases in patients with estrogen or progesterone receptor-positive breast cancer, hormonal agents such as tamoxifen, anastrozole, letrozole, exemestane, or luteinizing hormone-releasing hormone agonists (in premenopausal women) can be used for effective palliation lasting many months. Newer drugs that target growth factor pathways in breast cancer are currently in development. [...]