Health Questions and Answers

Archive for October, 2008

Question: How does Helicobacter pylori produce mucosal damage?

Thursday, October 30th, 2008

Answer: The organism generally does not directly invade the epithelial cells but indirectly makes the gastric mucosa more vulnerable to acid peptic damage by disrupting the mucous layer, liberating a variety of enzymes and toxins, and adhering to and altering the gastric epithelium. In addition, the host immune response to H. pylori incites an inflammatory […]

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Question: Where in the gastrointestinal (GI) tract does Helicobacter pylori live?

Thursday, October 30th, 2008

Answer: The organism lives within or beneath the gastric mucous layer, somewhat protected from stomach acid. H. pylori has potent urease activity, which hydrolyzes urea to ammonia and bicarbonate and increases its resistance to the stomach’s low pH environment. H. pylori recognizes and binds to specific receptors expressed by gastric epithelial cells and, therefore, is […]

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