Health Questions and Answers

Question: Are there causes of fever other than infection?


Yes. Although infections are definitely the most common causes of fever, there are numerous other causes. Neoplastic diseases (e.g., leukemia, lymphoma, solid tumors) and collagen vascular diseases (e.g., giant cell arteritis, polyarteritis nodosa, systemic lupus erythematosus, rheumatoid arthritis) are the second and third most common causes of fever. Other causes include central nervous system lesions (e.g., stroke, intracranial bleed, trauma), factitious fever, drugs, and environmental heat exposure.

Reference: Sinkinson CA, Brusch JL, Fitzgerald FT: How to evaluate patients having fever without localizing signs or syraptoms. Emerg Med Rep 10:177-184, 1989.

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