Health Questions and Answers

Archive for the 'Nutrition and the Immune System' Category

Question: What are the effects of enteral feedings on the immune system?

Saturday, November 24th, 2007

Answer:
Enteral feeding is the body’s preferred route of nutrition. Compared to TPN, enterally fed patients have a lower number of septic complications, including bacteremia, abdominal abscess, and pneumonia. It is speculated that the beneficial effects are from prevention of mucosal atrophy and decreased bacterial translocation. But there is little proof in humans. It has been [...]

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Question: What effect does nutrition have upon prostaglandin synthesis?

Friday, November 23rd, 2007

Answer:
Several studies have shown that long-chain triglycerides and PUFAs in total parenteral nutrition (TPN) increase TNF-alpha, which can stimulate the fever and hypotension of septic shock. TNF production has also been shown to increase with the duration of TPN. PUFA turnover depends on the activity of phospholipases, whose activities are enhanced in trauma and sepsis. [...]

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Question: Can the immune system be stimulated or augmented with certain types of nutrition?

Thursday, November 22nd, 2007

Answer:
Yes. Nutrition in general supports the immune system and the provision of certain nutrients to stressed trauma patients has been shown to lower septic complications. A 1994 study showed a significantly decreased incidence of abdominal abscess and multi-organ failure after using an enteral formula enriched with glutamine, arginine, omega-3 PUFA, nucleotides, and branched-chain amino acids. [...]

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Question: What is the immune response to obesity and weight loss?

Thursday, November 22nd, 2007

Answer:
Obesity appears to be associated with impaired immunity. Overweight patients are at greater risk for infection and bacteremia. Obesity is a risk factor for poor wound healing following surgery. Impaired T-and B-cell function has been noted in comparison to non-obese patients. Obese children and adolescents have impaired delayed-type hypersensitivity, mitogen-stimulated lymphocyte proliferation, and bactericidal capacity [...]

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Question: What is the effect of fatty acid malnutrition on the immune system?

Wednesday, November 14th, 2007

Answer:
Essential fatty acid deficiency (EFAD) is associated with depressed inflammatory responses. For example, depressed neutrophil chemotaxis may be related to reduced generation of the arachidonate metabolite leukotriene B4 (LTB4). In animal studies, researchers have shown that neutrophils from EFAD rats and monkeys showed decreased membrane depolarization and superoxide anion formation and depressed bactericidal capacity. Alpha-linolenic [...]

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Question: What particular vitamin deficiency are associated with decreased immune response?

Wednesday, November 14th, 2007

Answer:
Vitamin A has been the most extensively studied. Its deficiency causes declines in cellular immunity, as measured by delayed hypersensitivity skin testing. As the deficiency progresses, humoral immunity, as measured by serum immunoglobulin M (IgM) responses to a protein antigen (hemocyanin), also decline. Vitamin A antagonizes some of the deleterious effects of steroids on immunity [...]

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Question: Why is zinc important to the immune system?

Wednesday, November 14th, 2007

Answer:
Zinc has important effects on the immune system and on wound healing. Zinc deficiency causes a profound suppressive effect on thymic function, T-lymphocyte development, lympho-proliferation, T-cell dependent B-cell functions, and resistance to infections. Conversely, zinc supplementation has been shown to enhance certain immune responses in people. Animal studies also confirm this fact. In mice, immunosuppression [...]

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