Answer: Phentermine, a norepinephrine agonist (15-30 mg/day) Sibutramine, a combination norepinephrine/serotonin reuptake blocker (5, 10, and 15 mg; start with 10 mg and titrate) Orlistat, a pancreatic lipase inhibitor (120 mg 3 times/day before meals) Reference: Larson PR, et al: Williams Textbook of Endocrinology, 10th ed. Philadelphia, W.B. Saunders, 2003.
Archive for the 'Obesity' Category
Answer: Typically, the first approach is diet and exercise with behavioral modifications followed by the addition of pharmacotherapy. Pharmacotherapy should be considered in patients with a BMI over 30, a BMI over 27 with comorbidities, or minimal response after 6 months of lifestyle modifications. Reference: Larson PR, et al: Williams Textbook of Endocrinology, 10th ed. [...]