Answer:
Yes-non-Hodgkin’s lymphoma. The lymphomas are usually B cell-derived, and some patients also have serum protein spikes. The diagnosis of tumor may be difficult, given that the nonmalignant lymphoid infiltration of lymphocytes often simulates neoplasm (pseudolymphoma).
Reference: Talal N: Sjögren’s syndrome and connective tissue diseases association with other immunologic disorders. In McCarty DJ, Koopman WJ (eds): Arthritis [...]

Answer:
If symptoms of an underlying connective tissue disease do not appear within 12 months of the keratoconjunctivitis sicca, the chances are approximately 10% that it will appear later in life.
Reference: Talal N: Sjögren’s syndrome and connective tissue diseases association with other immunologic disorders. In McCarty DJ, Koopman WJ (eds): Arthritis and Allied Conditions, 12th ed. [...]

Answer:
Many believe that Sjögren’s syndrome is underdiagnosed. The first step is to ask the appropriate historical questions. Inquiries about eye grittiness or the ability to eat crackers without water have been suggested as nonleading ways to ask about dryness. Schirmer’s test can document diminished output of the lacrimal glands. Likewise, biopsy of the salivary glands [...]

Answer:
Sjögren’s syndrome is an inflammatory disease of exocrine glands manifested primarily by dryness of the eyes and mouth. It can occur as an isolated entity (primary Sjögren’s syndrome) or in association with another rheumatic disease, commonly RA or SLE (secondary Sjögren’s syndrome).
Reference: Koopman WJ (ed): Arthritis and Allied Conditions: A Textbook of Rheumatology, 15th ed. [...]