Health Questions and Answers

Question: Are metastatic bone lesions osteoblastic or osteolytic?

Answer:

Renal cell carcinoma and multiple myeloma tend to be purely lytic, prostate carcinoma tends to be mainly blastic, and the others are mixed. Tumors that are lytic are most often associated with hypercalcemia, whereas blastic metastases are not generally associated with this complication.

Reference:  DeVita T Jr, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology, 6th ed. Philadelphia, Lippincott Williams & Wilkins, 2001

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