Answer:

In the past there have been advocates for other agents, particularly phenytoin. However, a randomized controlled trial in women with eclampsia clearly favored MgSO4 over phenytoin for recurrent seizure prophylaxis.

Reference:

1. Witlin AG, Sibai BM: Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 92:883-889, 1998. Medline Similar articles Full article
2. Lucas MJ, Leveno KJ, Cunningham FG: A comparison of magniesuium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med 333:201, 1995. Medline Similar articles Full article

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