Health Questions and Answers

Question: What are anti-CCP antibodies?

Answer:

Antibodies directed against the citrullinated portion of certain molecules (filaggrin and fibrin among others) have been found in the sera of patients with RA and are called anti-cyclic citrullinated peptide antibodies. They are present in about 66% of RA patients and in fewer than 5% of control subjects making them quite specific for RA. Their clinical usefulness seems to be in helping to distinguish true RA in patients who are otherwise seronegative, or if the exact diagnosis of an inflammatory arthropathy is otherwise unclear.

Reference:  Harris ED, Budd RC, Firestein GS, et al (eds): Kelley’s Textbook of Rheumatology, 7th ed. Philadelphia, W.B. Saunders, 2005.

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