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Question: What are COX-2 anti-inflammatory drugs?


Recently two subtypes of COX have been described. The traditionally recognized enzyme, designated COX-1, seems to be most involved with normal cellular processes, often described as housekeeping functions. COX-2 seems to be involved more specifically in the synthesis of inflammatory mediators. It is normally not easily detectable in tissue and is thought to be “upregulated” under inflammatory conditions.

Reference: Hochberg MC (ed). Rheumatology, 3rd ed. St. Louis, Mosby, 2003.

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