Health Questions and Answers

Question: What are the long-term implications of Helicobacter pylori infection?

Answer:

Patients chronically infected with H. pylori frequently develop gastric and duodenal ulcer disease, especially the latter. Although less common, B-cell lymphoma and adenocarcinoma of the stomach are also associated with chronic gastritis due to H. pylori. Antral-predominant corpus sparing chronic gastritis due to H. pylori is more often associated with duodenal ulcer. Gastritis involving the entire stomach with intestinal metaplasia and achlorhydria is associated with gastric ulcer and cancer. B-cell lymphoma is often seen in conjunction with H. pylori infection and very often resolves with eradication of the bacteria.

Reference:
Graham DY: H. pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: A model. Gastroenterology 113:1983-1991, 1997.

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