Health Questions and Answers

Question: What are the newest options for treatment of RA?


The newest options for the treatment of RA are anti-cytokine regimens. Three preparations (etanercept [Enbrel], infliximab [Remicade], and adalimunmab [Humira]) target TNF-α and one targets IL-1R (anakinra [Kineret]). All of these options are given parenterally and are fairly expensive. Anakinra, although proven efficacious, requires daily injections and has a slower onset of action and is therefore used less frequently.

Reference: Harris ED, Budd RC, Firestein GS, et al (eds): Kelley’s Textbook of Rheumatology, 7th ed. Philadelphia, W.B. Saunders, 2005

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