Health Questions and Answers

Question: What are the predisposing factors for infection in patients with cancer?

Answer:

Predisposing factors for infection include defects in cellular and humoral immunity, organ compromise due to tumor-related obstruction, chemotherapy-related granulocytopenia, disruption of mucosal (e.g., respiratory and alimentary tract) and integumental surfaces, iatrogenic procedures or placement of prosthetic devices, central nervous system dysfunction, and hyposplenic or postsplenectomy states.

Reference:  Casciato DA, Lowitz BB (eds): Manual of Clinical Oncology, 5th ed. Boston, Little, Brown, 2000.

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