Health Questions and Answers

Question: What effects does estrogen have on bone?

Answer:

Estrogen increases bone growth, especially in the axial skeleton. Growth hormone has more effect on the long bones. As a result of this, hypogonadal patients often have a short trunk as compared to their arm span and lower extremity length (eunichoid habitus). Growth hormone-deficient subjects often have the opposite appearance. Estrogen also promotes fusion of the epiphyseal plates. Patients with precocious puberty have an early growth advantage, but ultimately have short stature due to premature epiphyseal closure if left untreated.

Reference:

  1. Clark PA, Rogol AD: Growth hormones and sex steroid interactions at puberty. Endocrinol Metab Clin North Am 25:665-681, 1996. Medline Similar articles
  2. Frisch R, Revelle R: Height and weight at menarche and a hypothesis of menarche. Arch Dis Child 46:695-701, 1971. Medline Similar articles

Leave a Reply