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Question: What factors affect renal calcium excretion?


With some exceptions, renal calcium handling varies directly with renal Na+ handling. Therefore, renal calcium excretion is increased by saline diuresis, loop diuretics, and volume expansion. In contrast, renal calcium excretion is decreased in volume depletion and other states associated with renal salt retention. One notable exception to this general rule is that the natriuresis associated with thiazide diuretics is accompanied by decreased, rather than increased, urinary calcium excretion.

Reference: Schrier RW (ed): Renal and Electrolyte Disorders, 6th ed. Philadelphia, Lippincott Williams & Wilkins, 2003.

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