Health Questions and Answers

Question: What is onychodystrophy? With which diseases is it associated?

Answer:

Separation of the nail plate, usually beginning at the free margin and progressing proximally, is called onychodystrophy. Both systemic and local processes are associated with this finding, including hypo- and hyperthyroidism, pregnancy, syphilis, trauma (particularly clawing), psoriasis, SLE, atopic dermatitis, eczema, use of solvents (including nail hardeners), and mycotic, pyogenic, or viral infections.

Reference: Domonkos AN, et al: Diseases of the skin appendages. In Andrews’ Diseases of the Skin: Clinical Dermatology, 7th ed. Philadelphia, W.B. Saunders, 1982, pp 930-984.

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