Health Questions and Answers

Question: What is subacute cutaneous lupus (SCLE)?


Some consider this cutaneous eruption on a spectrum between chronic discoid lupus and acute cutaneous lupus. The lesions generally occur on the shoulders, upper chest, and neck and are symmetric and nonscarring. They can be annular and resemble psoriasis. Between 25% and 50% of patients have constitutional symptoms, and they may have circulating antibodies to Ro antigen. SCLE is associated with HLA-DRW3.

Reference: McCauliffe DP, Sontheimer RD: Subacute cutaneous lupus erythematosus. In Wallace DJ, et al (eds): Dubois’ Lupus Erythematosus, 4th ed. Philadelphia, Lea & Febiger, 1993, pp 302-309.

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