Health Questions and Answers

Question: Which chemotherapy agents are used in the treatment of metastatic breast cancer?

Answer:

Among the most effective chemotherapy agents for breast cancer are doxorubicin, epirubicin, paclitaxel, docetaxel, vinorelbine, cyclophosphamide, methotrexate, fluorouracil, capecitabine, and prednisone. These agents are used singly or in combination in the treatment of advanced or metastatic breast cancer. If the tumor overexpresses the Her/neu oncogene, trastuzumab (Herceptin) may be added to improve the effectiveness of chemotherapy.

Reference: Casciato DA, Lowitz BB (eds): Manual of Clinical Oncology, 5th ed. Boston, Little, Brown, 2000.

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