Health Questions and Answers

Question: With what is severe folate deficiency most often associated?


Severe folate deficiency occurs most often in association with chronic alcoholism, celiac sprue, tropical sprue, and blind loop syndrome. Minor deficiencies can be found in Crohn’s disease and following partial gastrectomy. Since folate absorption is largely completed in the upper small intestine, malabsorption is worse in disorders that affect the upper gut. However, any intestinal disorder accompanied by a decrease in dietary intake or rapid transport may result in folate deficiency.

Reference:  Rustgi AK (ed): The Requisites in Gastroenterology: Vol 1: Esophagus and Stomach. St. Louis, Mosby, 2003.

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