Although no laboratory test is absolutely diagnostic for a rheumatic disease, the presence of certain autoantibodies in the appropriate clinical setting can be helpful. Some common disease associations include:
SLE, neonatal lupus syndrome, subacute lupus, Sjögren’s syndrome, RA
Polymyositis with pulmonary involvement
Reference: Craft J, et al: Antinuclear antibodies. In Kelly WN, et al (eds): Textbook of Rheumatology, 4th ed. Philadelphia, W.B. Saunders, 1993, pp 164-187.