Health Questions and Answers

Question: Why is it helpful to know which specific ANA is present in a given patient?

Answer:

Although no laboratory test is absolutely diagnostic for a rheumatic disease, the presence of certain autoantibodies in the appropriate clinical setting can be helpful. Some common disease associations include:
Ro/SSA
DS DNA
Sm
Jo-1
Centromere
SCL-70
SLE, neonatal lupus syndrome, subacute lupus, Sjögren’s syndrome, RA
SLE
SLE
Polymyositis with pulmonary involvement
CREST syndrome
Systemic sclerosis 

Reference: Craft J, et al: Antinuclear antibodies. In Kelly WN, et al (eds): Textbook of Rheumatology, 4th ed. Philadelphia, W.B. Saunders, 1993, pp 164-187. 

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